Spiro-3-hetero-azolones for treatment of diabetic complications

Details Spiro-3-hetero-azolones for treatment of diabetic complications Spiro-3-hetero-azolones for treatment of diabetic complications

C - Chemistry, Metallurgy

07

D

260/315.05, 260/

C07D 235/02 (2006.01) C07D 263/52 (2006.01) C07D 277/60 (2006.01)

Patent

CA 1204763

ABSTRACT OF THE DISCLOSURE Spiro-oxazolidones, -thiazolidones and -imidazolidones of the formula below are prepared which are useful as aldose reductase inhibitors and as therapeutic agents for the treatment of complications arising from diabetes: Image I and the pharmaceutically acceptable salts thereof, wherein U is oxygen, sulfur or nitrogen substituted with hydrogen or alkyl having 1-4 carbon atoms; n is zero or one; R is hydrogen or alkyl having 1-4 carbon atoms; W is carbonyl or hydroxymethylene; X is hydrogen, bromo, chloro, iodo, alkyl having 1-4 carbon atoms, di- methyl or (CH2)mQ wherein m is 1 or 2 and Q is phenyl or halo- phenyl, with the proviso that when X is dimethyl, n is one; Y is hydrogen, halo, nitro, trifluoromethyl, alkoxy having 1-4 carbon atoms or alkyl having 1-4 carbon atoms; Z is hydrogen, halo, nitro, trifluoromethyl, alkoxy having 1-4 carbon atoms or alkyl having 1- 4 carbon atoms, with the proviso that is either Y or Z is nitro the other is hydrogen.

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