Stressed polymeric device for controlled release of a...

Details Stressed polymeric device for controlled release of a... Stressed polymeric device for controlled release of a...

A - Human Necessities

61

K

167/165

A61K 9/70 (2006.01) A61K 9/00 (2006.01)

Patent

CA 1312284

PC (Ph) 7116 STRESSED POLYMERIC DEVICE FOR CONTROLLED RELEASE OF A SUBSTANCE TO AN AMBIENT ENVIRONMENT Abstract A matrix device for controlled release of at least one active agent to an ambient environment, said matrix comprising an active agent - or agents - containing polymer which has been subjected to tensile stress. Included is a laminate device comprising at least one matrix as core sheet, said core sheet or sheets com- prising the active agent or agents in a polymer matrix which has been subjected to stress and, in a further embodiment, a porosity enhancing agent in admixture with said agent; the core sheet or sheets being alternately sandwiched or interposed between coextensive inert polymeric films substantially impermeable to said environment and to said agent or agents, said device being perforated by one or a plurality of macroholes extending through said sheets and said films. Also included are methods for making such a device.

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