Quinolone acids, processes for their preparation and...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/10 (2006.01) C07D 215/56 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07F 9/58 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 1216849

Quinolone acids, processes for their preparation and antibacterial agents containing these compounds ABSTRACT OF THE DISCLOSURE The invention relates to quinolone carboxylic acids of the formula (I) Image (I) in which A represents straight-chain or branched alkylene with 1 to 6 carbon atoms or a radical Image , R1 represents alkoxycarbonyl with 1 to 6 carbon atoms in the alkyl part, benzyloxycarbonyl, carboxyl, optionally substituted carbamoyl, cyano, dialkoxyphosphonyl or alkylsulphonyl with 1 to 4 carbon atoms in the alkyl part and R2 represents hydrogen, alkoxycarbonyl with 1 to 6 carbon atoms in the alkyl part, benzyloxycarbonyl, optionally substituted carbamoyl, cyano, chlorine, acetyl, alkyl with 1 to 3 carbon atoms or phenyl, or R1 and R2, together with the carbon atom which they substitute, can also form a 2-oxo-tetrahydrofuryl ring, and R3, R4, R5 and R6 can be identical or different and represent hydrogen, methyl, ethyl or n- or i-propyl and X represents hydrogen, halogen, preferably fluorine or chlorine, or nitro. The invention also relates to pharmac- eutical compositions containing said quinolone carboxylic acids and the use of said compounds and compositions for treatment of bacterial infection. Also included in the invention are process for the manufacture of the active quinolone carboxylic acids.

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