Selective serotonin uptake inhibitors

Details Selective serotonin uptake inhibitors Selective serotonin uptake inhibitors

C - Chemistry, Metallurgy

07

C

167/245, 167/276

C07C 211/30 (2006.01) A61K 31/135 (2006.01)

Patent

CA 1336287

The present invention provides 1-phenyl- (naphthalenyl)alkylamines of the Formula I: Image I wherein: each of R1 and R2 independently is hydrogen or methyl; R3 is hydrogen, halo, C1-C4 alkyl, C1-C3 alkoxy or trifluoromethyl; each R4 independently is hydrogen, halo, C1-C4 alkyl, C1-C3 alkoxy or trifluoromethyl; m is 1 or 2; when m is 2, each R4 can be combined to form methylenedioxy; x is 2-5; pharmaceutically acceptable acid addition salts thereof; and pharmaceutical formulations comprising compounds of Formula I as defined above, as the active ingredient. These compounds are selective inhibitors of serotonin uptake, and are therefore useful in treating conditions such as obesity, depression, alcoholism, loss of memory and anxiety.

583703

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