Preparation of a pharmaceutically active pyridazine derivative

Details Preparation of a pharmaceutically active pyridazine derivative Preparation of a pharmaceutically active pyridazine derivative

C - Chemistry, Metallurgy

07

D

260/264.1

C07D 237/20 (2006.01) C07D 487/04 (2006.01)

Patent

CA 1212947

- 1 - "PREPARATION OF A PHARMACEUTICALLY ACTIVE PRYIDAZINE DERIVATIVE" ABSTRACT OF THE DISCLOSURE A novel method of preparing ethyl{6-[ethyl-(2- hydroxypropyl)amino]-3-pyridazinyl}hydrazinecarboxylate is disclosed, wherein 7-chloro-3-methyl-4-oxo-4H- pyridazino[6,1-c][1,2,4]triazine is treated with ethyl-(2-hydrixypropyl)amine. The corresponding amino derivative is hydrolized in mild conditions and the hydrazino compound thus obtained is suitably acylated.

452025

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