Therapeutic peptides

Details Therapeutic peptides Therapeutic peptides

C - Chemistry, Metallurgy

07

K

530/7.04

C07K 7/04 (2006.01) A61K 38/22 (2006.01) C07K 14/46 (2006.01) C07K 14/575 (2006.01)

Patent

CA 1340988

A linear peptide which is an analog of a naturally occurring, biologically active bombesin having an active site and a binding site responsible for binding of bombesin to a receptor on a target cell, cleavage of a peptide bond in the active site of the naturally occurring peptide being unnecessary for in vivo biological activity, the analog having a non-peptide bond instead of a peptide bond between an amino acid of the active site and an adjacent amino acid, and having the same binding site as the naturally occurring peptide, so that the analog, is capable of acting as a competitive inhibitor of naturally occurring bombesin by binding to the receptor and, by virtue of the non-peptide bond, failing to exhibit the in vivo activity of naturally occurring bombesin.

578389

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