Bis-esters of methanediol with acetonides of ampicillin or...

Details Bis-esters of methanediol with acetonides of ampicillin or... Bis-esters of methanediol with acetonides of ampicillin or...

C - Chemistry, Metallurgy

07

D

260/118.5

C07D 499/80 (2006.01) C07D 499/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 1178575

P.C. (ChRe) 6358/6359 BIS-ESTERS OF METHANEDIOL WITH ACETONIDES OF AMPICILLLIN OR AMOXICILLIN AND PENICILLANIC ACID 1,1-DIOXIDE Abstract Bis-esters of methanediol wherein one hydroxy group of the methanediol is esterified with the carboxy group of hetacillin (or of the p-hydroxy analog of hetacillin) and the other hydroxy group of the methanediol is esterified with penicillanic acid 1,1-dioxide. These orally effective compounds have a particularly broad spectrum of antibacterial activity in mammals, and have an unusually long serum half- life.

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