Process of preparing basically substituted pyridazines and...

C - Chemistry – Metallurgy – 07 – D

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260/245.7, 260/2

C07D 237/22 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 1173033

Abstract Process of preparing pharmacologically valuable basically substituted pyrid- azines of the general formula I Image (I), wherein R1, R2, R3 and R4 independently of one another have the meanings given in claim 1 and the acid addition salts thereof, by reacting a compound of the general formula V Image (V) wherein Z represents Image or Image and Hal denotes halogen, with a compound of the general formula IV Image (IV) or a compound of the general formula VI Image (VI) with a compound of the general formula IX Image (IX) and, if appropriate, subsequent conversion to the acid addition salt. The new compounds of formula I and their acid addition salts possess valuable pharmaceutical properties, in particular a strong .beta.-adrenalytic cardioselec- tive action.

391595

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