Process for the production of 7-alkyl indoles

Details Process for the production of 7-alkyl indoles Process for the production of 7-alkyl indoles

C - Chemistry, Metallurgy

07

D

260/319.7

C07D 209/08 (2006.01)

Patent

CA 1217196

PROCESS FOR THE PRODUCTION OF 7-ALKYL INDOLES ABSTRACT OF THE DISCLOSURE Process for the production of 7-alkyl indoles by the catalytic dehydrocyclization of 2,6-dialkyl anilines having the formula: Image wherein X is -C2H5, -C3H7 or -C4H9 and Y is -CnH2n+1, wherein n is 1 to 4. The 2,6-dialkyl aniline is dehydrocyclized, without the addition of oxygen or an oxygen-containing gas, in the presence of steam and a catalyst. The catalyst contains at least one alkali metal carbonate or hydroxide and/or an alkaline earth metal oxide as well as at least one of the following compounds: Cr2O3, V2O5, Co3O4, CuO, Fe2O3, Al2O3, ZnO, BaCrO4, TiO2, ZrO2 and copper chromite. The catalyst has been activated with barium oxide or mixtures of constituents including barium oxide at a temperature between 500° and 700°C. and at a pressure between 10 mm Hg and 10 atmospheres. The molar ratio of the steam to the starting material is within the range of 3 to 1 to 75 to 1. The raw product obtained by the dehydrocyclization is subjected in a further step to a partial hydrogenation by means of a hydrogenation catalyst.

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