C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/235.01
C07D 257/04 (2006.01) C07D 317/14 (2006.01)
Patent
CA 1209134
ABSTRACT This invention relates to compounds having the following formula (I) Image (I) wherein R is chosen from the group a) a free or esterified carboxy group b) -C(OR')3, where each R' group is independently C1-C6 alkyl or phenyl; c) -CH2-R", where R" is hydroxy or C2-C7 alkoxy; d) Image where Ra and Rb are chosen independently from the group hydrogen, C1-C6 alkyl, C2-C6 alkanoyl and phenyl; e -C?N; f) a Image radical; g) -CHO; h) a Image radical where each X' is independently-O- or -S- and the R'a and R'b groups, whether the same or different, are C1-C6 alkyl or together form a straight or branched C2-C6 alkylene chain; D is chosen from the group: -CH2-, ?CH-OH Image (cis), Image (trans), -C?C-, ?C=O, -O-, -S-, and ?N-RC, where RC may be hydrogen, C1-C6 alkyl or C2-C6 alkanoyl; one of R1 and R2 and, independently, one or R3 and R4 is hydrogen, C1-C6 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, phenyl, or aryl-C1-C6 alkyl and the other is hydrogen, hydroxy, C1-C6 alkoxy or aryl C1-C6 alkoxy, or R1 and R2 and, independently, R3 and R4 together form an oxo group; each R5 and R6, whether the same or different, may be hydrogen, C1-C6 alkyl or halogen. or R5, R6 and the carbon atom to which they are bound form a ?C=CH2 or Image radical; Y is chosen from the group: -CH2-CH2-, -C?C-, Image (trans), Image (cis) where Z is hydrogen or halogen, -NH-CO- and -NH-CH2-; X is chosen from the group: Image in which m is zero or 1, Image (cis), Image (trans), -O-, -S- and ?N-Rc which Rc as defined above; m1, m2, n1, and n2, whether the same or different, may be zero or an integer between 0 and 12 such that each sum m1+m2 and n1+n2 is less than or equal to 15; p and q are independently zero or an integer between 1 and 3 such that the sum p + q is an integer of 1 to 6; R7 is chosen from the group: a') hydrogen; b') C1-C4 alkyl; c') a cycloaliphatic radical, either unsubstituted or substituted with one or more C1-C6 alkyl or C1-C6 alkoxy; d') an aryl group, either unsubstituted or substituted with one or more of the following: halogen,halo-C1-C6-alkyl, C1-C6-alkyl, C1-C6-alkoxy, phenyl; e') a saturated or unsaturated heterocyclic ring, either unsubstituted or substituted with one or more of the following: halogen, halo-C1-C6-alkyl, C1-C6-alkoxy, phenyl, C1-C6 alkyl; as well as the lactones derived from compounds with formula (I) and the pharmaceutically or veterinarily acceptable salts thereof. It also relates to a process for the preparation of these compounds and to intermediates use- ful in this process. The compounds of formula (I) are useful in medicine due to their/broncho dilator luteolytic, anti-ulcerogenic and platelet anti- aggregant activity.
401255
Ceserani Roberto
Faustini Franco
Fava William
Fumagalli Angelo
Gandolfi Carmelo
Farmitalia Carlo Erba S.p.a.
Fetherstonhaugh & Co.
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