Anthelmintic bioconversion products

Details Anthelmintic bioconversion products Anthelmintic bioconversion products

C - Chemistry, Metallurgy

12

P

195/109, 167/185

C12P 19/62 (2006.01) A01N 43/24 (2006.01) A01N 43/90 (2006.01) C07H 17/08 (2006.01) C07H 19/01 (2006.01)

Patent

CA 1339481

There are disclosed new compounds with significant antiparasitic activity which are prepared by fermenting 13-epi-ivermectin aglycone in a novel microorganism identified as Streptomyces avermitilis MA-5542. The 13-epi-ivermectin aglycone compounds are modified by the microorganism by methylation at the 5-hydroxy position and the addition of an a-L-oleandrose at the 13-position hydroxy. The compounds are significant antiparasitic and anthelmintic agents and compositions for that use are also disclosed.

615344

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