Salts of antimalarial phenanthrenemethanol

Details Salts of antimalarial phenanthrenemethanol Salts of antimalarial phenanthrenemethanol

C - Chemistry, Metallurgy

07

F

167/250, 167/274

C07F 9/09 (2006.01) A61K 31/135 (2006.01) C07D 453/04 (2006.01)

Patent

CA 1249296

SALTS OF ANTIMALARIAL PHENANTHRENEMETHANOL COMPOUNDS ABSTRACT The compounds of formula (I) Image wherein R1 is hydrogen or an alkyl radical containing one to six carbon atoms; R2 is an alkyl radical containing one to six carbon atoms; and X is H2O3POCH(CH2OH)2, n[HO2CCH(OH)CH(OH)CO2H] wherein n is 1/2 or 1, and 2HO2CC6H7(OH)4, possess markedly increased activity against malaria-causing parasites. Pharmaceutical compositions and method of treatment of subjects with malaria are also disclosed.

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