Indole derivatives

Details Indole derivatives Indole derivatives

C - Chemistry, Metallurgy

07

D

167/228, 260/207

C07D 451/00 (2006.01) A61K 31/435 (2006.01) C07D 209/08 (2006.01) C07D 403/12 (2006.01) C07D 451/04 (2006.01) C07D 451/12 (2006.01) C07D 451/14 (2006.01) C07D 453/02 (2006.01)

Patent

CA 1337415

Compounds of formula (I), and pharmaceutically acceptable salts thereof: Image (I) wherein L is NH or O; X and Y are independently selected from hydrogen or C1-4 alkyl, or together are a bond; R1 and R2 are independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl-C1-4 alkyl, or together are C2-4 polymethylene; R3 and R4 are independently selected from hydrogen, halogen, CF3, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-7 acyl, C1-7 acylamino, C1-6 alkylsulphonylamino, N-(C1-6 alkylsulphonyl)-N-C1-4 alkylamino, C1-6 alkylsulphinyl, hydroxy, nitro or amino, aminocarbonyl, aminosulphonyl, aminosulphonylamino or N-(aminosulphonyl)-C1-4 alkylamino optionally N-substituted by one or two groups selected from C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4 alkyl, phenyl or phenyl C1-4 alkyl groups or optionally N-disubstituted by C4-5 polymethylene; - 2 - Z is a group of formula (a), (b) or (c) Image (a) Image (b) Image (c) wherein n is 2 or 3; p is 1 or 2; q is 1 to 3; r is 1 to 3; and R5 or R6 is C1-7 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-2 alkyl or C2-7 alkenyl-C1-4 alkyl; having 5-HT M-receptor antagonist activity, a process for their preparation and their use as pharmaceuticals.

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