Conjugates associating, by covalent bond, an enzyme with an...

Details Conjugates associating, by covalent bond, an enzyme with an... Conjugates associating, by covalent bond, an enzyme with an...

A - Human Necessities

61

K

167/139, 167/103

A61K 39/44 (2006.01) A61K 47/48 (2006.01) C12N 11/06 (2006.01)

Patent

CA 1216791

PATENT APPLICATION entitled : New conjugates associating, by covalent bond, an enzyme with an antibody, and medicinal associations using the said conjugates. in the names of : Franz JANSEN Pierre GROS assignee : Société anonyme styled : SANOFI ABSTRACT OF THE DISCLOSURE The present invention relates to new immunoenzymic conjugates resulting from a chemical coupling, by covalent bond, of an antibody or a fragment of antibody, which has retained the capacity of recognizing the selected antigen, with an enzyme capable of producing ammonium ions from natural substrates which are well tolerated in higher animal organisms. The invention also relates to a process for the preparation of these conjugates and the medicinal associations of said conjugates with an immunotoxin.

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