Recombinant dna vectors encoding a 4"-0-isovaleryl acylase...

Details Recombinant dna vectors encoding a 4"-0-isovaleryl acylase... Recombinant dna vectors encoding a 4"-0-isovaleryl acylase...

C - Chemistry, Metallurgy

12

N

195/1.22, 195/1.

C12N 15/55 (2006.01) C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12N 15/76 (2006.01)

Patent

CA 1336693

The carE gene of Streptomyces thermotolerans has been isolated and used to construct recombinant DNA expression vectors. The carE gene encodes 4''-O- isovaleryl acylase activity important in the bio- synthesis of a number of useful antibiotics. The carE gene can be used not only to construct recombinant cells with an increased ability to produce the acylase enzyme but also to construct recombinant cells with the ability to produce novel antibiotic compounds.

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