C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/129, 530/7.0
C07K 7/08 (2006.01) A61K 39/015 (2006.01) C07K 7/06 (2006.01) C07K 14/445 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1316631
ABSTRACT OF THE DISCLOSURE A mixture of the synthetic peptide compounds of the formulas: Formula (I) Tyr-Gly-Gly-Pro-Ala-Asn-Lys-Lys-Asn-Ala-Gly-OH, Formula (II) Asp-Glu-Leu-Glu-Ala-Glu-Thr-Gln-Asn-Val-Tyr-Ala-Ala-NH2, and Formula (III) Tyr-Ser-Leu-Phe-Gln-Lys-Glu-Lys-Met-Val-Leu-NH2, and compositions thereof, induces antibodies against the late stages of Plasmodium falciparum malaria and provides protection against infection with this parasite, thus providing a synthetic malaria vaccine for Plasmodium falciparum induced malaria. A synthetic protein copolymer vaccine, polymerized from a monomer which is a hybrid of formulas (II), (III) and (I), and which also includes the (Asn-Ala-Asn-Pro) sequence of the CS protein between formulas (II) and (III) and Formulas (lII) and (I) of the monomer, has been shown to provide safe and complete self-limiting protection in human volunteers against the asexual blood stages of P. falciparum induced malaria.
556435
Patarroyo Manuel E.
Ridout & Maybee Llp
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