Inhibition of the 5-lipoxygenase pathway

Details Inhibition of the 5-lipoxygenase pathway Inhibition of the 5-lipoxygenase pathway

C - Chemistry, Metallurgy

07

D

167/231, 167/237

C07D 207/22 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1296005

ABSTRACT OF THE DISCLOSURE A diaryl-substituted imidazole fused to a thiazole, pyrrole, thiazine or pyridine ring, or pharmaceutical compositions thereof, are useful in inhibiting the 5-lipoxygenase pathway in an animal in need thereof by administration of an effective, 5-lipoxygenase pathway inhibiting amount of such compound. In particular, the inhibiting compound and pharmaceutical compositions thereof will alleviate the 5-lipoxygenase pathway mediated disease state of rheumatoid arthritis. These compounds do not share the ulcerogenic liability or toxicity of other compounds such as corticosteroids which are used in the treatment of the 5-lipoxygenase pathway.

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