Sulfonyldecahydro-8h-isoquino-¬2,1-g|¬1,6|- naphthyridines,...

Details Sulfonyldecahydro-8h-isoquino-¬2,1-g|¬1,6|- naphthyridines,... Sulfonyldecahydro-8h-isoquino-¬2,1-g|¬1,6|- naphthyridines,...

C - Chemistry, Metallurgy

07

D

167/211, 260/246

C07D 455/03 (2006.01) A61K 31/47 (2006.01) C07D 471/14 (2006.01) C07D 491/147 (2006.01) C07D 491/22 (2006.01)

Patent

CA 1331459

ABSTRACT OF THE DISCLOSURE Compounds of the formula (I): Image (I) in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy, and R is lower alkyl, optionally substituted phenyl, -(CH2)mOR1 or -NR1R2, wherein m is an integer of 1 to 6 and R1 and R2 are independently hydrogen or lower alkyl, or the group -NR1R2 forms a heterocycle of the formula: Image wherein A is -CH2-, -NR1- or oxygen, wherein R1 has the above meaning and the wavy lines indicate that the hydrogen atom attached thereto is in either the .alpha.- or .beta.-position; or a pharmaceutically acceptable salt thereof, are useful as selective .alpha.2-blockers.

563919

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