Process for preparing 3-hydroxy-ml-236b derivatives known as...

C - Chemistry – Metallurgy – 12 – P

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C12P 7/42 (2006.01) C12P 7/62 (2006.01) C12P 17/06 (2006.01)

Patent

CA 1186647

ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) Image , that is to say M-4 carboxylic acid and M-4' carboxylic acid, as well as pharmaceutically acceptable salts and esters thereof and the corresponding ring closed lactones may be prepared by contacting an ML-236B compound with a microorganism of the genus Nocardia or a cell-free, enzyme-containing extract thereof and then, if necessary, subjecting the resulting product to one or more of the following reactions: hydrolysis, salification, esterification and lactonisation.

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