Tetrahydronaphthaline and indane derivatives

Details Tetrahydronaphthaline and indane derivatives Tetrahydronaphthaline and indane derivatives

C - Chemistry, Metallurgy

07

C

260/489, 260/653

C07C 13/28 (2006.01) A61K 31/015 (2006.01) A61K 31/035 (2006.01) C07C 13/465 (2006.01) C07C 13/48 (2006.01) C07C 25/24 (2006.01) C07C 25/28 (2006.01) C07C 35/32 (2006.01) C07C 35/36 (2006.01) C07C 39/23 (2006.01) C07C 43/215 (2006.01) C07C 43/23 (2006.01) C07C 45/72 (2006.01) C07C 49/683 (2006.01) C07C 49/697 (2006.01) C07C 49/747 (2006.01) C07C 205/06 (2006.01)

Patent

CA 1305176

RAN 4060/140 Abstract Compounds of the general formula Image I wherein X and Y represent -CH2- or >C(CH3)2; Z represents a residue -CHR8-, >CO, >CR8OR7, -CHR8-CHR8-, -CHOR7-CH2-, -CO-CHOR7 or -CHOR7-CHOR7-; R1 represents fluorine, chlorine, iodine, o-bromo, m-bromo, lower-alkoxy, acyloxy, nitro, hydroxy, amino, lower-alkylamino, di-lower-alkylamino or phenyl; or lower alkyl in the o- or m-position; R2 and R3 represent hydrogen, lower-alkyl, trifluoromethyl or halogen and one of the residues R2 and R3 represents hydrogen, trifluoromethyl or lower-alkyl, R4 and R5 represent hydrogen, alkyl, alkoxy or halogen; R6 represents hydrogen, halogen, lower-alkyl or a residue -OR7; R7 represents hydrogen, lower-alkyl or acyl: R8 represents hydrogen or lower-alkyl; m represents a whole number of 0 to 5: several residues R1, R7 or R8 present can be different from one another; R6 is hydrogen when simultaneously Z is -CH2-CH2- and m = 0; with the exception of 1,2,3,4 tetrahydro-1,1,4,4 -tetramethyl-6-(.alpha.-methyl- styryl)naphthalene and its derivatives which are hydroxylated in the terminal phenyl ring, are obtained by a Wittig reaction from corresponding monocyclic and bicyclic components and optional subsequent transformation of substituents. The compounds have therapeutic, e.g. anti-neoplastic, activity.

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