Fibroblast growth factor antagonists

Details Fibroblast growth factor antagonists Fibroblast growth factor antagonists

C - Chemistry, Metallurgy

12

N

530/7.06, 530/7.

C12N 15/18 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1328840

FIBROBLAST GROWTH FACTOR ANTAGONISTS ABSTRACT OF DISCLOSURE Antagonists to bovine pituitary fibroblast growth factor, a 146 amino acid residue polypeptide, are produced. These antagonists are between 4 and 45 residues in length, are characterized by their ability to a) interact with the FGF receptor and/or b) bind heparin and/or c) inhibit and therefore modulate endothelial cell growth. They include either the four residue sequence which forms basic FGF(36-39), namely Pro-Asp-Gly-Arg, or the four residue sequence which constitutes basic FGH(107-110), namely Arg-Ser-Arg-Lys. They are also antagonistic to acidic FGF.

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