C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/327.3
C07D 339/00 (2006.01) C07C 45/46 (2006.01) C07C 49/84 (2006.01) C07D 339/06 (2006.01) C07D 339/08 (2006.01) C07D 409/04 (2006.01)
Patent
CA 1057295
ABSTRACT OF THE DISCLOSURE Compounds of the formula Image I wherein R represents a group of the formula Image or Image (a) (b) in which R1, R2 and R3 each represent a hydrogen or fluorine, chlorine, bromine or iodine atom or a lower alkyl, lower alkoxy, aryl-(lower alkoxy), phenyl, nitro, trifluoromethyl, hydroxy, cyano, di(lower alkyl)amino, lower alkanoyloxy or two adjacent R1, R2 and R3 symbols together represent a methyl- enedioxy, ethylenedioxy or butadien-1,3-ylene-1,4 group, R4 represents a hydrogen atom or a lower alkyl group, R5, R6 and R7 each represent a hydrogen or fluorine, chlorine, bromine or iodine atom or a lower alkyl or lower alkoxy group or two adjacent R5, R6 and R7 symbols together represent an ethylene- dioxy group, X represents a sulphur atom, SO or SO2, Y represents a straight- chain or branched-chain, optionally hydroxy-substituted, aliphatic group con- taining 2-8 carbon atoms, of which 2-4 carbon atoms are present in the chain, and Z represents a straight-chain or branched-chain, optionally hydroxy-sub- stituted, aliphatic group containing 1-6 carbon atoms, of which 1-4 carbon atoms are present in the chain, m stands for zero or 1 and n stands for 2 or 3, and pharmaceutically acceptable acid addition salts thereof, as well as process for their preparation are disclosed. These compounds possess coronary-dilating properties.
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