Naphthalenylthiazole derivatives

Details Naphthalenylthiazole derivatives Naphthalenylthiazole derivatives

C - Chemistry, Metallurgy

07

D

260/308.5

C07D 277/34 (2006.01)

Patent

CA 1211116

-19- ABSTRACT OF THE DISCLOSURE Disclosed herein are new aldose reductase inhibitors of the formula Image wherein R is Image or IMAGE> wherein R1 is lower alkyl; R2 is halo and R3 is hydrogen, or R2 and R3 each is a substituent at positions 3, 4, 5 or 6 of the naphthalene ring selected fromthe group consisting of lower alkoxy, trihalomethyl, and halo; and R4 is lower alkyl. The derivatives are useful for treating or preventing diabetic complications.

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