Process for the preparation of lmw-heparin

Details Process for the preparation of lmw-heparin Process for the preparation of lmw-heparin

C - Chemistry, Metallurgy

12

P

195/139

C12P 19/26 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1334081

A method for production of low molecular weight heparin (LMW-heparin) by enzymatic batch depolymerization of heparin with heparinase wherein heparin is depolymerized to a desired weight average molecular weight by depolymerization to the corresponding number average molecular weight. The method enables depolymerization to a desired weight average molecular weight by measuring the increase in UV-absorption (preferably at 230-235 nm) .DELTA.A235 and halting the depolymerization when .DELTA.'A235 has reached the calculated value corresponding to the desired number average molecular weight Mn.

536096

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