Process for the preparation of .beta.-lactam compounds

Details Process for the preparation of .beta.-lactam compounds Process for the preparation of .beta.-lactam compounds

C - Chemistry, Metallurgy

07

D

260/102, 260/111

C07D 498/04 (2006.01) C07D 499/00 (2006.01) C07D 499/72 (2006.01) C07D 501/57 (2006.01) C07D 505/00 (2006.01)

Patent

CA 1267138

ABSTRACT The present invention provides a process for the substitution of an acylamino .beta.-lactam compound at the carbon atom carrying the acylamino group, which process comprises reacting the .beta.-lactam compound with an halogenating agent and a nucleophilic reagent; characterised in that the acylamino group has an acidic group on the carbon atom adjacent the carbonyl group. In particular the process of this invention comprises reacting a .beta.-lactam of partial structure (I): Image (I) where X represents an acidic group; with an halogenating agent and a nucleophilic reagent.

443072

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