Tetraenyl prostaglandins

Details Tetraenyl prostaglandins Tetraenyl prostaglandins

C - Chemistry, Metallurgy

07

C

167/205, 260/235

C07C 405/00 (2006.01) A61K 31/557 (2006.01)

Patent

CA 1261827

TETRAENYL PROSTAGLANDINS ABSTRACT OF THE DISCLOSURE This invention encompasses prostaglandins of the formula Image wherein R represents hydrogen or lower alkyl having 1 to 6 carbon atoms; R1 represents hydrogen, vinyl, or lower alkyl having 1 to 4 carbon atoms and the wavy line represents R or S stereochemistry; R2, R3, and R4 are hydrogen or lower alkyl having 1 to 4 carbon atoms or R2 and R3 together with carbon Y form a cycloalkenyl having 4 to 6 carbon atoms or R3 and R4 together with carbons X and Y form a cycloalkenyl having to 6 carbons. Compounds of this invention have potent gastric antisecretory and cytoprotective properties with unexpectedly low diarrheogenic side effects.

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