Sustained release lithium-containing tablets and method for...

Details Sustained release lithium-containing tablets and method for... Sustained release lithium-containing tablets and method for...

A - Human Necessities

61

K

167/292

A61K 9/22 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 33/00 (2006.01)

Patent

CA 1200502

- 11 - ABSTRACT SUSTAINED RELEASE LITHIUM-CONTAINING TABLETS AND METHOD FOR THEIR MANUFACTURE The release pattern of sustained release lithium carbonate tablets is improved by using a particular form of lithium carbonate material. This should have acicular crystals with a substantially monomodal particle size distribution in which the curve showing volume percentages of particles of different sizes shows a peak at a particle diameter of between 10 and 25 µm. Moreover not more than 20% by volume of the material should have a particle diameter above 30 µm. A pre- ferred sustained release agent is a mixture of glyceryl mono- di- and tri-esters of straight chain saturated fatty acids. The tablets may be made by a moist granulation technique, followed by screening to ensure a granulate of appropriate grain sizes, after which the granulate is compacted into tablets. Fig. 4.

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