Extrusion techniques for producing liposomes

Details Extrusion techniques for producing liposomes Extrusion techniques for producing liposomes

A - Human Necessities

61

K

167/163, 134/50

A61K 9/127 (2006.01)

Patent

CA 1264668

ABSTRACT OF THE DISCLOSURE Extrusion techniques for producing populations of liposomes having a substantially unimodal size distribution and for producing unilamellar liposomes are provided. The unimodal size distribution is achieved by repeatedly passing previously formed liposomes through one or a plurality of filters, all of which have the same pore size. The unilamellar liposomes are produced by using a filter which has a pore size equal to or less than about 100 nm. In accordance with other aspects of the disclosure, liposomes are prepared directly from a lipid powder or pellet and buffer without the use of any solvents, detergents or other extraneous materials.

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