Inactivated target cells, methods of using same and vaccines...

Details Inactivated target cells, methods of using same and vaccines... Inactivated target cells, methods of using same and vaccines...

G - Physics

01

N

167/130, 167/41

G01N 33/536 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/554 (2006.01) G01N 33/569 (2006.01)

Patent

CA 1200485

INACTIVATED TARGET CELLS, METHODS OF USING SAME AND VACCINES AND DIGNOSTIC KITS CONTAINING SAME ABSTRACT OF THE DISCLOSURE The present invention describes the inactivation of target cells by treatment of said cells with psoralens and irradiation with long wave length ultraviolet light. The inactivated cells are shown to be antigenic and are shown to be non-infective. These cells are useful as target antigens for in vitro assays of cellular immunity. Diagnostic kits containing the inactivated, target cells are prepared for use in serologic assays. Since the inactivated cells are immunogenic and non-infective, they are also useful as vaccines.

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