Glutarimide antianxiety and antihypertensive agents

Details Glutarimide antianxiety and antihypertensive agents Glutarimide antianxiety and antihypertensive agents

C - Chemistry, Metallurgy

07

D

167/211, 260/279

C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 1244418

ABSTRACT Glutarimide derivatives of the formula which are useful antihypertensive and antianxiety agents Image wherein R1 and R2 each independently represent hydrogen, a 1 to 4 carbon alkyl, a 1 to 4 carbon alkoxy, halogen, nitro, hydroxy, S03H, S02NH2, and then R1 and R2 are taken together, form a fused phenyl group at the 1,2- or 3,4- positions, with the proviso that when R1 and R2 are identical they each represent a hydrogen, a 1 to 4 carbon alkyl, a 1 to 4 carbon alkoxy, hydroxy or a halogen group; A and B independently represent an oxo, a thio or an imino group having the formula -N(R6)- wherein the R6 group is hydrogen or a 1 to 4 carbon alkyl group; R3 is a hydrogen, a 1 to 4 carbon alkyl or hydroxyethyl group; n is an integer of from 2 to 5; and R4 and R5 represent methyl groups or when taken together form a cyclopentane or cyclohexane ring; its enantiomers; and the pharmaceutically acceptable acid addition salts thereof.

487290

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