Process for preparing alpha-aspartic acid amides

Details Process for preparing alpha-aspartic acid amides Process for preparing alpha-aspartic acid amides

C - Chemistry, Metallurgy

07

C

260/525.2

C07C 237/00 (2006.01)

Patent

CA 1202980

PROCESS FOR PREPARING ALPHA-ASPARTIC ACID AMIDES DAVID B. REITZ ABSTRACT A novel process for preparing alpha-aspartic acid amides, particularly those suitable as non-nutritive sweeteners. This process involves the coupling reaction of an alpha-aspartate ester and a beta-hydroxy primary amine. The ester is reacted with the amine, one of which is preferably in stoichiometric excess, in a liquid phase system to form the alpha-aspartic acid amide. The amide is then recovered from the liquid phase system.

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