C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/135, 530/15.
C07K 19/00 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C12N 9/00 (2006.01) C12N 11/00 (2006.01)
Patent
CA 1341018
A potent and specific immunotoxin is prepared by coupling an inactivated diphtheria toxin to a binding moiety such as a monoclonal antibody or transferrin. The immunotoxins are specific for human tumors and leukemias and are indistinguishable in cell toxicity from that of the native toxin linked to the binding domain without the toxicity to other cells. The immunotoxin is useful in treating graft versus host disease as well as selectively killing tumor cells, such as medulloblastoma and glioblastoma cells.
608247
Greenfield Larry
Johnson Virginia G.
Laird Walter
Youle Richard J.
Centers For Dise The Government Of The United States Of America As Represented By
Cetus Corporation
Gowling Lafleur Henderson Llp
Greenfield Larry
Laird Walter
LandOfFree
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