A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/172, 167/231
A61K 31/44 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01) A61K 47/02 (2006.01) C07D 401/12 (2006.01)
Patent
CA 1327010
Abstract of the Disclosure The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula Image (wherein R1 is hydrogen, alkyl, halogen, cyano, carboxy, carbo- alkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R2 is hydro- gen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, di- alkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R3 and R5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4) and a basic inorgainic magnesium and/or calcium compound, is physically stable.
529605
Hirai Shin-Ichiro
Makino Tadashi
Tabata Tetsuro
Fetherstonhaugh & Co.
Takeda Pharmaceutical Company Limited
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