Stable formulation of biologically active proteins for...

C - Chemistry – Metallurgy – 07 – K

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167/103.1, 167/1

C07K 14/565 (2006.01) A61K 47/00 (2006.01) A61K 47/12 (2006.01) C07K 14/55 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1295245

Abstract of the Disclosure A pharmaceutical composition containing IL-2 or IFN-P dissolved in a suitable carrier medium at pH 7.0 to 8.0 stabilized with sodium laurate is suitable for parenteral injection into humans or animals. This formulation may be prepared by adding to either protein, after its recovery from a transformed organism, an effective amount of sodium laurate at a pH of 9 to 9.5 and then adjusting the pH of the formulation to between 7.0 and 8Ø

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