Phenyl-substituted piperidine compounds and their...

Details Phenyl-substituted piperidine compounds and their... Phenyl-substituted piperidine compounds and their...

Category

C - Chemistry, Metallurgy

Subcategory

07

Subsubcategory

D

CPC

167/228, 260/292

IPC codes

C07D 211/20 (2006.01) A61K 31/445 (2006.01) C07D 211/22 (2006.01) C07D 405/12 (2006.01)

Type

Patent

Patent number

CA 1323367

Description

28 ABSTRACT Novel piperidine compounds having the formula Image wherein R3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more C1-6-alkyl, C1-6-alkoxy, C3-8-cycloalkyl, C3-5-alkylene or aral- koxy, R1 is straight or branched C1-8-alkyl, C4-8-alkoxy-C4-8-al- kyl, C4-7-cycloalkyl, aryloxy-C3-8-alkyl, C4-8-alkenyl, or C4-8-cycloalkylalkyl, or R1 may also be hydrogen or C1-3- alkyl, when R3 is aryl, which is substituted with two or more of C1-6- alkyl, C1-6-alkoxy, C3-8-cycloalkyl, aralkoxy, or with C3-5- alkylene. X is hydrogen or halogen, and wherein Y is O or S and a salt thereof with a pharmaceutically acceptable acid. The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.

Application Number

550834

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