Protein having cell growth stimulating action composition...

C - Chemistry – Metallurgy – 12 – P

Patent

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530/15.04, 195/1

C12P 21/00 (2006.01) A61K 38/00 (2006.01) C07K 14/195 (2006.01) C07K 14/21 (2006.01) C07K 14/24 (2006.01) C07K 14/245 (2006.01) C07K 14/255 (2006.01) C07K 14/28 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C07K 14/32 (2006.01) C07K 14/33 (2006.01) C07K 14/335 (2006.01) C07K 14/34 (2006.01)

Patent

CA 1224435

ABSTRACT OF THE DISCLOSURE A protein which is characterized by the following properties: (i) having a molecular weight of from about 5,000 to about 160,000 when the value is obtained from a calib- ration curve showing a relationship between the molecular weight and the amount eluted obtained by means of high- performance liquid chromatography using as marker pro- teins; thioglobin (with a molecular weight (M.W.) of 670,000), bovine .gamma.-globulin (with a M.W. of 158,000) fowl ovoalbumin (with a M.W. of 44,000), equine myoglobin (with a M.W. of 17,000), and vitamin B12 (with a M.W. of 1,350); (ii) composed predominantly of neutral and acidic amino acids and containing significant amounts of glutamic acid and aspartic acid as the acidic amino acids; (iii) having a cell growth stimulating activity; and (iv) being substantially free of nucleoside phos- photransferase, which is useful as a wound treatment agent and a promoting agent in the synthesis of DNA, and so forth.

448163

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