Process for preparing n-pyrrolyl-pyridazineamine derivatives

Details Process for preparing n-pyrrolyl-pyridazineamine derivatives Process for preparing n-pyrrolyl-pyridazineamine derivatives

C - Chemistry, Metallurgy

07

D

260/264.1, 260/2

C07D 403/00 (2006.01) C07D 237/20 (2006.01) C07D 413/14 (2006.01)

Patent

CA 1173442

ABSTRACT The present invention refers to a new process for preparing N-2,3,4,5-substituted-1H-pyrrol-1-yl)-6-substituted amino-3-pyridazineamine, known as antihypertensive agents. The process is characterized in that a suitable 3,6-diha- logenopyridazine is reacted with hydrazine hydrate or other hydrazine derivatives of formula NH2 NHR, the obtained compound is reacted with a suitable dicarbonyl compound yielding first an alcandlone-bis- -[6-halogen-3-pyridazinyl]hydrazone, and then a 6-halogen- -3-pyrrolylpyridazineamine derivative which is in turn reacted with an amine to yield the desired compounds.

392819

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