C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
150/15.1
C12Q 1/26 (2006.01) C07C 271/22 (2006.01) C07D 209/20 (2006.01) C07K 5/06 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 1197165
ABSTRACT OF THE DISCLOSURE Provided by this invention are amide compounds of the formula Image (I) where R1 is a lower alkyl group and R2 is a substituted methylamino group or a D-amino acid residue, and salts thereof. These compounds are useful in the assaying of leucine aminopeptidase (LAP). The invention also provides an assay method for leucine aminopeptidase which comprises reacting a substrate amide compound or salt thereof of the formula (I) Image wherein R1 is a lower alkyl group and R2 is a substituted methylamino group or a D-amino acid residue, with a sample for leucine aminopeptidase assay, incubating the reaction product substituted methylamine compound or D-amino acid with the corresponding oxidase, and measuring the thus consumed oxygen or liberated hydrogen peroxide.
374692
Fujii Tadashiro
Katsuragi Shigeo
Matsumoto Kazuhiko
Matsumoto Kunio
Noda Toshiharu
Gowling Lafleur Henderson Llp
Toyo Jozo Kabushiki Kaisha
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