Synthetic substrate and assay method of enzyme activity

Details Synthetic substrate and assay method of enzyme activity Synthetic substrate and assay method of enzyme activity

C - Chemistry, Metallurgy

12

Q

150/15.1

C12Q 1/26 (2006.01) C07C 271/22 (2006.01) C07D 209/20 (2006.01) C07K 5/06 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 1197165

ABSTRACT OF THE DISCLOSURE Provided by this invention are amide compounds of the formula Image (I) where R1 is a lower alkyl group and R2 is a substituted methylamino group or a D-amino acid residue, and salts thereof. These compounds are useful in the assaying of leucine aminopeptidase (LAP). The invention also provides an assay method for leucine aminopeptidase which comprises reacting a substrate amide compound or salt thereof of the formula (I) Image wherein R1 is a lower alkyl group and R2 is a substituted methylamino group or a D-amino acid residue, with a sample for leucine aminopeptidase assay, incubating the reaction product substituted methylamine compound or D-amino acid with the corresponding oxidase, and measuring the thus consumed oxygen or liberated hydrogen peroxide.

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