C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/35
C07J 1/00 (2006.01) C07J 13/00 (2006.01) C07J 75/00 (2006.01)
Patent
CA 1306993
ABSTRACT OF THE DISCLOSURE A process for the production of 17?-ethinyl-17?- hydroxy-18-methyl-4,15-estradien-3-one is described comprising reacting a 17-enolester of formula II Image II. wherein R1 represents an alkyl radical with 1-3 carbon atoms and R2 represents an acyl or a trialkylsilyl group with 1-10 carbon atoms under palladium catalysis, with compounds of formula III Image III, wherein R1 represents an alkyl radical with 1-3 carbons atoms, reducing the 17-keto group to the 17-hydroxy group in a manner known in the art, reducing the aromatic A-ring according to Birch, with liquid ammonia, to 3-methoxy- 2,5(10),15-estratrien-17.beta.;-ol, reoxidizing the 17-hydroxy group to the 17-keto group, ethinylating the 17-keto group and splitting off the 3-enolether to form 17?- ethinyl-17.beta.-hydroxy-18-methyl-4,15-estradiene-3-one.
562962
Bohlmann Rolf
Hofmeister Helmut
Laurent Henry
Wiechert Rudolf
Marks & Clerk
Schering Aktiengesellschaft
LandOfFree
Process for the production of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the production of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1208309