1,3 - dioxan - 4 - ylalkenoic acids

Details 1,3 - dioxan - 4 - ylalkenoic acids 1,3 - dioxan - 4 - ylalkenoic acids

C - Chemistry, Metallurgy

07

D

167/244, 260/351

C07D 319/04 (2006.01) A61K 31/335 (2006.01) C07C 33/30 (2006.01) C07C 59/48 (2006.01) C07D 319/06 (2006.01) C07D 319/08 (2006.01) C07D 493/10 (2006.01)

Patent

CA 1259323

A B S T R A C T 1,3-DIOXAN-4-YLALKENOIC ACIDS This invention concerns novel 1,3-dioxan-4-yl- alkenoic and alkanoic acids of formula I wherein Ra is (1-6C)alkyl, halogeno-(1-6C)alkyl, Rb is hydrogen or as Ra, or Ra and Rb together form (2-5C)polymethylene or (2-4C)oxypolymethylene, n is 2,3 or 4, A is vinylene or ethylene, benzene ring B optionally bears a single substituent and the substituents at positions 4 and 5 of the dioxane ring have trans-relative stereochemistry; together with pharmaceutically acceptable salts, (1-6C)- alkyl esters and (1-6C)alkanesulphonamides thereof. The compounds of formula I are antagonists of thromboxane A2 and are of value in treating a variety of disease conditions. The invention also provides processes for the manufacture of, and pharmaceutical compositions of, the compounds of formula I.

466832

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