Topically active compositions of double-stranded rnas

Details Topically active compositions of double-stranded rnas Topically active compositions of double-stranded rnas

A - Human Necessities

61

K

167/202

A61K 31/70 (2006.01) A61K 9/107 (2006.01) A61K 31/765 (2006.01) A61K 38/19 (2006.01) C07H 21/00 (2006.01)

Patent

CA 1327001

ABSTRACT Surfactant-stabilized ternary complexes of dsRNAs in topical pharmaceutical compositions, optionally also including a lymphokine and/or an inhibitor of reverse transcriptase, are applied topically to the affected or exposed area to treat or prevent viral infections, such as herpes virus, and other infectious conditions, particularly venereally transmitted pathogens. Ternary complexes of two strands of complementary RNA plus a compatible surfactant stabilized against temperature-associated enzymatic inactivation are described.

574263

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