Transdermal absorption dosage unit for narcotic analgesics...

Details Transdermal absorption dosage unit for narcotic analgesics... Transdermal absorption dosage unit for narcotic analgesics...

A - Human Necessities

61

M

167/159, 167/227

A61M 37/00 (2006.01) A61K 9/70 (2006.01) A61K 31/485 (2006.01)

Patent

CA 1309659

ABSTRACT TRANSDERMAL ABSORPTION DOSAGE UNIT FOR NARCOTIC ANALGESICS AND ANTAGONISTS AND PROCESS FOR ADMINISTRATION Transdermal absorption morphinan narcotic analgesic or antagonist pharmaceutical polymer matrix dosage units have been developed which comprise a backing layer and an adjoining layer of a solid polymer matrix in which minimum effective doses of morphinan narcotic analgesic or antago- nist pharmaceuticals are microdispersed and transdermally supplied. A presently preferred analgesic is hydromoprhone. The dosage units use a biologically acceptable adhesive polymer means to adhere the dosage units to the subject to be treated. The polymer matrix has dispersed one or more skin permeation enhancers. The invention also provides a process for transdermal absorption of said pharmaceuticals in at least minimum dosage amounts.

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