Process for producing human epidermal growth factors and...

Details Process for producing human epidermal growth factors and... Process for producing human epidermal growth factors and...

C - Chemistry, Metallurgy

12

N

530/7.1, 530/15.

C12N 15/18 (2006.01) C07K 14/485 (2006.01) C12N 15/62 (2006.01) C12N 15/71 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1269055

ABSTRACT OF THE DISCLOSURE Disclosed is a process for producing a fusion protein comprising epidermal growth factor (EGF) attached through a Glu-residue to a leader. Treatment of the fusion protein with a Staphylococcus aureus V8 protease specific for cleaving peptides at a Glu-linkage produces large amounts of the 53 amino acid EGF sequence. The treatment conditions optimize production of the 53 and 51 amino acid EGFs relative to shorter analogs, and take full advantage of the selectivity of the protease.

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