Ethynylheteroaromatic acids having retinoic acid-like activity

Details Ethynylheteroaromatic acids having retinoic acid-like activity Ethynylheteroaromatic acids having retinoic acid-like activity

C - Chemistry, Metallurgy

07

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C07D 213/79 (2006.01) C07D 213/30 (2006.01) C07D 213/48 (2006.01) C07D 213/51 (2006.01) C07D 213/55 (2006.01) C07D 213/80 (2006.01) C07D 307/54 (2006.01) C07D 307/68 (2006.01) C07D 333/24 (2006.01) C07D 333/38 (2006.01)

Patent

CA 1326853

ABSTRACT Retinoid-like activity is exhibited by compounds of the formula Image wherein A is pyridyl, furyl, thienyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, -COOH and its esters, amides and pharmaceutically acceptable salts, -CHO and its acetal derivatives, -COR1 and its ketal derivatives where R1 is -(CH2)nCH3 where n is defined above, or -CH2OH and its ether and acyl ester derivatives; or a pharmaceutically acceptable salt.

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