Compositions and methods for administering therapeutically...

Details Compositions and methods for administering therapeutically... Compositions and methods for administering therapeutically...

A - Human Necessities

61

K

167/149, 167/243

A61K 31/375 (2006.01) A61K 31/34 (2006.01) A61K 45/08 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01)

Patent

CA 1341434

A composition useful for administering therapeutically active compounds to improve the body absorption and/or retention thereof comprises a pharmaceutically effective amount of a therapeutically active compound, which does not exhibit Vitamin C activity, and has a molecular weight below about 5,000, an acidic functional group and a pKa of <=6 at physiological pH = 7.4 normally eliminated unmetabolized via the renal tubular secretion pathway far organic anions, and at least one compound selected from the group consisting of L-threonic, L-xylonic and L-lyxonic acids, and the edible non-toxic salts, aldono-lactones and aldono-lactides thereof in an amount effective to increase the body absorption rate of said active compound.

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