Physiologically active compositions

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A - Human Necessities

61

K

167/139

A61K 39/395 (2006.01) C07K 14/615 (2006.01) C07K 16/26 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1259923

ABSTRACT It has previously been shown that bivalent antibodies to insulin can mimic the action of insulin in vivo. However antibodies in vivo were believed to have the opposite effect. It has now been found that the administration to vertebrates of certain specific anti-hormone antibodies, preferably monoclonal antibodies, with or without administration of the hormone itself, can potentiate the biological action of the hormone. Active immunisation with a fragment of the hormone can also be carried out. Such methods can be used therapeutically or alternatively to increase the response of the vertebrate to the hormone beyond normal physiological levels. When the hormone is growth hormone, accelerated growth of economically important animals can be achieved.

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