Recombinant dna-derived bordetella toxin subunit analogs

Details Recombinant dna-derived bordetella toxin subunit analogs Recombinant dna-derived bordetella toxin subunit analogs

C - Chemistry, Metallurgy

12

N

167/137, 530/15.

C12N 15/31 (2006.01) A61K 39/10 (2006.01) A61P 31/04 (2006.01) C07K 14/235 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1341560

The development of subunits and subunit analogs of the Bordetella exotoxin by recombinant DNA techniques provides vaccine products that retain their biological activity, are highly immunogenic, and can confer protection against disease challenge. Genetically-engineered modifications of the subunits can result in products that retain immunogenicity, yet are free of enzymatic activity associated with toxin of reactogenicity.

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