Condensed, seven-membered ring compounds and their use

Details Condensed, seven-membered ring compounds and their use Condensed, seven-membered ring compounds and their use

C - Chemistry, Metallurgy

07

D

260/238.6, 260/2

C07D 281/08 (2006.01) C07D 209/48 (2006.01) C07D 281/10 (2006.01) C07D 417/04 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1209993

Abstract Novel condensed, seven-membered ring compounds of the formula: Image [wherein R1 and R2 each represent hydrogen, halogen, tri- fluoromethyl, lower alkyl or alkoxy, or both jointly form tri- or tetramethylene; R3 is hydrogen, lower alkyl or aralkyl; R4 is hydrogen or alkyl, aralkyl or cyclo- alkylalkyl which may be substituted; X is a group represented by the formula S(O)n (where n is an integer of 0 to 2); Y is a carboxyl group which may be esterified or amidated; m is 1 or 2] and salts thereof. These compounds exhibit inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of hypertension.

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