Process for the preparation of n-acetyl-p-aminophenol

C - Chemistry – Metallurgy – 07 – C

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260/557

C07C 231/02 (2006.01) C07C 233/25 (2006.01)

Patent

CA 1297129

IMPROVED PROCESS FOR THE PREPARATION OF N-ACETYL-P-AMINOPHENOL Abstract of the Disclosure An improved process for the preparation of N-acetylp-aminophenol. p-Aminophenol is acetylated in an aqueous medium to produce a crude aqueous reaction mixture and N-acetyl-p-aminophenol product is recovered by crystal- lization from an aqueous system comprising the reaction mixture. Crystals are separated from the crude mother liquor which contains residual N-acetyl-p-aminophenol and unreacted acetic acid. According to the improvement, residual N-acetyl-paminophenol and acetic acid are recovered from the crude mother liquor by liquid-liquid extraction with a water-immiscible organic solvent to produce an extract containing N-acetyl-p-aminophenol and acetic acid. The extract is distilled to strip off the solvent and acetic acid.

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