Synthetic peptides derived from the alpha-subunit of human...

Details Synthetic peptides derived from the alpha-subunit of human... Synthetic peptides derived from the alpha-subunit of human...

C - Chemistry, Metallurgy

07

K

530/7.04, 530/7.

C07K 7/08 (2006.01) C07K 14/59 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1327095

ABSTRACT Synthetic peptides corresponding to .alpha.-subunit of human glycoprotein hormone amino acid regions .alpha.31-45, .alpha.21-35, .alpha.26-46 and .alpha.81-92; were found to inhibit binding of 125I-bTSH to human thyroid. Peptides corresponding to regions .alpha.26-46 and .alpha.31-45 were also found to potently inhibit the stimulation of adenylate cyclase activity by bTSH in a TSH bioassay using FRTL-5 cells and block the action of thyroid stimulating immunoglobulin.

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